The Partnership was born from the recognition that NCDs are now the major contributor to the global burden of disease. They kill at least 40 million people each year, the equivalent to 70% of all deaths globally. Each year, there are 15 million “premature” deaths (i.e., below the age of 70 years) from NCDs. Continuing with business as usual will increase this by a third by 2030. NCDs are not just medical problems. They have huge personal, social and economic impacts and their rising prevalence is a serious setback for human and national development.